SKN7 of Candida albicans: mutant construction and phenotype analysis.

نویسندگان

  • Praveen Singh
  • Neeraj Chauhan
  • Anup Ghosh
  • Freddie Dixon
  • Richard Calderone
چکیده

The SKN7 two-component response regulator gene of Candida albicans was deleted, and the phenotype of the mutant was established. This mutant exhibited impaired growth on Spider agar and 10% serum agar compared to wild-type and gene-reconstituted strains. The skn7 mutant was sensitive to H(2)O(2) in vitro, but its virulence was only mildly attenuated. A comparison of the Skn7p and Ssk1p response regulators of C. albicans is discussed.

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عنوان ژورنال:
  • Infection and immunity

دوره 72 4  شماره 

صفحات  -

تاریخ انتشار 2004